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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPH2
All Species:
27.58
Human Site:
Y446
Identified Species:
43.33
UniProt:
Q8IWU9
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IWU9
NP_775489.2
490
56057
Y446
I
T
R
P
F
S
V
Y
F
N
P
Y
T
Q
S
Chimpanzee
Pan troglodytes
XP_522470
490
55999
Y446
I
T
R
P
F
S
V
Y
F
N
P
Y
T
Q
S
Rhesus Macaque
Macaca mulatta
Q2HZ26
490
56076
Y446
I
T
R
P
F
S
V
Y
F
N
P
Y
T
Q
S
Dog
Lupus familis
XP_538286
708
77776
H664
I
T
R
P
F
S
V
H
F
N
P
Y
T
Q
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8CGV2
488
55899
Y444
I
T
R
P
F
S
V
Y
F
N
R
Y
T
Q
S
Rat
Rattus norvegicus
Q8CGU9
485
55603
Y441
I
T
R
P
F
S
V
Y
F
N
P
Y
T
Q
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519524
444
50785
Y401
K
R
P
F
G
V
Y
Y
N
P
Y
T
Q
S
V
Chicken
Gallus gallus
P70080
445
51121
Y402
K
R
P
F
G
V
K
Y
N
P
Y
T
Q
S
V
Frog
Xenopus laevis
Q92142
481
55388
K437
I
Q
R
P
F
G
L
K
Y
N
P
F
T
Q
S
Zebra Danio
Brachydanio rerio
NP_999960
473
54279
Y429
I
K
R
P
F
S
V
Y
Y
D
P
Y
T
Q
S
Tiger Blowfish
Takifugu rubipres
NP_001027849
486
55494
Y442
I
K
R
P
F
S
V
Y
Y
N
P
Y
T
Q
S
Fruit Fly
Dros. melanogaster
P17276
452
51642
F409
A
N
S
I
P
R
P
F
G
V
R
Y
N
A
Y
Honey Bee
Apis mellifera
XP_394674
508
57954
R440
I
Q
R
P
F
G
L
R
Y
N
P
Y
T
Q
S
Nematode Worm
Caenorhab. elegans
P90925
457
52111
Y414
N
R
P
F
Q
I
R
Y
N
A
Y
T
Q
R
V
Sea Urchin
Strong. purpuratus
XP_784134
479
54807
R435
I
K
R
P
F
E
V
R
Y
D
P
Y
T
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.7
58.9
N.A.
93
93.6
N.A.
68.3
68.5
68.7
72.2
80
48.5
56.6
46.7
53.2
Protein Similarity:
100
99.5
99.1
63.7
N.A.
95.3
96.7
N.A.
79.8
80.8
83.2
83
88.5
66.1
70.8
65.5
69.5
P-Site Identity:
100
100
100
93.3
N.A.
93.3
100
N.A.
6.6
6.6
60
80
86.6
6.6
66.6
6.6
60
P-Site Similarity:
100
100
100
100
N.A.
93.3
100
N.A.
6.6
6.6
80
93.3
93.3
13.3
80
13.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
0
0
0
7
0
0
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
14
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
20
74
0
0
7
40
0
0
7
0
0
0
% F
% Gly:
0
0
0
0
14
14
0
0
7
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% H
% Ile:
74
0
0
7
0
7
0
0
0
0
0
0
0
0
0
% I
% Lys:
14
20
0
0
0
0
7
7
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
14
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
7
0
0
0
0
0
0
20
60
0
0
7
0
0
% N
% Pro:
0
0
20
74
7
0
7
0
0
14
67
0
0
0
0
% P
% Gln:
0
14
0
0
7
0
0
0
0
0
0
0
20
67
0
% Q
% Arg:
0
20
74
0
0
7
7
14
0
0
14
0
0
7
0
% R
% Ser:
0
0
7
0
0
54
0
0
0
0
0
0
0
20
74
% S
% Thr:
0
40
0
0
0
0
0
0
0
0
0
20
74
0
0
% T
% Val:
0
0
0
0
0
14
60
0
0
7
0
0
0
0
20
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
67
34
0
20
74
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _